• Project entitled: “Ultrasound responsive mesoporous Mn@Silica nano capsules for targeted therapeutics” funded by DBT under Ramalingaswami Re-entry fellowship for the duration 2021-2026 (42.5 lakhs).

Major Areas of Interest:

• Nanobiotechnology and Biomaterials

Other Areas of Interest:

• Theranostic Nanomaterials - Synthesis and Characterization
• Interfacial Nano-bio interactions of biomaterials
• 3D dynamic scaffolds for tissue engineering
• Engineered nanocarriers for nose-to-brain transport
• Ultrasound responsive nanocarriers for cancer therapy
• Bioactive nanofibers, metal composites and polymeric nanoparticles
• Design and validation of high-performance nanofiber-based filtration media and ballistic composites

Refereed Journal Publications:

• Vinith J., Sunil V., Uday Kumar S., Manoj K., “Surface-Engineered Extracellular Vesicles in Cancer Immunotherapy” Cancers (Basel). 2023 May; 15(10): 2838.
• Yi L., Uday Kumar S., Natacha J., Sumanth MS., Adith R., Negar S., Pinaki M., Anandi K., Tarik F M., Ramasamy P., “Inhaled Gold Nano-star Carriers for Targeted Delivery of Triple Suicide Gene Therapy and Therapeutic MicroRNAs to Lung Metastases: Development and Validation in a Small Animal Model”, Adv Ther., 5(8), 2200018, 2022.
• Negar S., Uday Kumar S., Tarik FM., Ramasamy P, “A rationally identified panel of microRNAs targets multiple oncogenic pathways to enhance chemotherapeutic effects in glioblastoma models”, Sci Rep., 12(1), 12017, 2022.
• Uday Kumar S., Arutselvan N., Tarik FM., Ramasamy P. FN3 linked nanobubbles as a targeted contrast agent for US imaging of cancer-associated human PD-L1”, J Control Release., 346, 317-327, 2022.
• Jagadesh CB., Uday Kumar S., Fernando GM., Yitian Z., Frezghi H., Jason RM., Sharon P., Tarik FM., Ramasamy P, “Engineered Cell-Derived Vesicles Displaying Targeting Peptide and Functionalized with Nanocarriers for Therapeutic microRNA Delivery to Triple-Negative Breast Cancer in Mice”, Adv Healthc Mater., 11(5), e2101387, 2022.
• Arsenii VT., Rehman A., Thurston B., Huaijun W., Jose GVM., Uday Kumar S., Ramasamy P., Jeremy J “Noninvasive estimation of local speed of sound by pulse-echo ultrasound in a rat model of nonalcoholic fatty liver”, D. Phys Med Biol., 67(1):10.1088/1361-6560/ac4562, 2022.
• Huaijun W., Zhongqian H., Uday Kumar S., Rajendran JCB., Arsenii T, Jeremy J., Ramasamy P., “Ultrasound-Guided Microbubble-Mediated Locoregional Delivery of Multiple MicroRNAs Improves Chemotherapy in Hepatocellular Carcinoma” Nanotheranostics 6(1)., 62, 2022.
• Uday Kumar S., K. Wang., N. Sadeghipour., T. F. Massoud., R. Paulmurugan A Microfluidics-Based Scalable Approach to Generate Extracellular Vesicles with Enhanced Therapeutic MicroRNA Loading for Intranasal Delivery to Mouse Glioblastomas ACS Nano., 2021., 15., 11., 18327–18346 .
• S. Uday Kumar., R. Afjei., K. W. Ferrara., T. F. Massoud and R. Paulmurugan Gold-Nanostar-Chitosan Mediated Delivery of a SARS-CoV-2 DNA Vaccine for Respiratory Mucosal Immunization: Development and Proof-of-Principle ACS Nano., 2021 15., 11., 17582–17601.
• S. Uday Kumar., H. Wang., A. V. Telichko., A. Natarajan., T. Bettinger., S. Cherkaoui., T. F. Massoud., J. J. Dahl., and R. Paulmurugan., Ultrasound Triggered Co-delivery of Therapeutic MicroRNAs and a Triple Suicide Gene Therapy Vector by using Biocompatible Polymer Nanoparticles for Improved Cancer Therapy in Mouse Models Adv. Ther. 2021., 4., 202000197.
• Liu Y.., S. Uday Kumar., A. Krishnan., T. F. Massoud., R. Paulmurugan Camouflaged Hybrid Cancer Cell-Platelet Fusion Membrane Nanovesicles Deliver Therapeutic MicroRNAs to Presensitize Triple-Negative Breast Cancer to Doxorubicin Adv. Funct. Mater. D.O.I. -10.1002/adfm.202103600
• Remote Control of Time‐Regulated Stretching of Ligand‐Presenting Nanocoils In Situ Regulates the Cyclic Adhesion and Differentiation of Stem Cells S. Min., M. J. Ko., H. J. Jung., W. Kim., S. B. Han., Y. Kim., G. Bae., S. Lee., R. Thangam., H. Choi., N. Li., J. E. Shin., Y. S. Jeon., H. S. Park., Y. J. Kim., S. Uday Kumar et al. Adv. Mater. 2021., 33(11)., 2008353
• S. Uday Kumar., R. J.C. Bose., S. Gambhir., T. Massoud., R. Paulmurugan. SP94-Targeted Triblock Co-Polymer Nanoparticle Delivers Thymidine Kinase-p53-Nitroreductase Triple Therapeutic Gene and Restore Anticancer Function against Hepatocellular Carcinoma in vivo. ACS Appl. Mater. Interfaces., 2020., 12., 10., 11307–11319.
• S. Uday Kumar., A. Telichko., H. Wang., D. Hyun., E. G. Johnson., M. S. Kent., R. B. Rebhun., J. J. Dahl., W. T. N. Culp., R. Paulmurugan. Acoustically Driven Microbubbles Enable Targeted Delivery of microRNA-Loaded Nanoparticles to Spontaneous Hepatocellular Neoplasia in Canines Adv. Ther. 2020., 3(12):2000120.
• J. C. B. Rajendra., N. Tharmalingam., F. J. G. Marques., S. Uday Kumar., Natarajan et. al. Reconstructed Apoptotic Bodies as Targeted “Nano Decoys” to Treat Intracellular Bacterial Infections within Macrophages and Cancer Cells ACS Nano., 2020., 17., 5., 5818–5835.
• A. V. Telichkoa., H Wang., S Bachawal., S. Uday Kumar., J. C. Bose., R. Paulmurugan., J. J. Dahl. Therapeutic Ultrasound Parameter Optimization for Drug Delivery Applied to a Murine Model of Hepatocellular Carcinoma Ultrasound Med. Biol. 2020., 47(2)., 309-322.
• J. C. Wischhusen., S. M. Chowdhury., T. Lee., H. Wang., S. Bachawal., R. Devulapally., R. Afjei., S. Uday Kumar., R. Paulmurugan. Ultrasound-Mediated Delivery of MiRNA-122 and Anti-MiRNA-21 Therapeutically Immunomodulate Murine Hepatocellular Carcinoma In Vivo J. Control. Release ., 2020., S0168-3659(20)30070-5.
• Kim S B., Hori S S., Sadeghipour N., S. Uday Kumar., Fujii R., Massoud T F., Paulmurugan R Highly sensitive eight-channel light sensing system for biomedical applications. Photochem Photobiol Sci. 2020., 15., 19(4)., 524-529.
• S. Uday Kumar., R. J.C. Bose., M. Malhotra., H. Babikir., R. Afjei., E. Robinson., Y. Zeng., E. Chang., F. Habte., R. Sinclair., S. Gambhir., T. Massoud., and R. Paulmurugan. Intranasal Delivery of Targeted Polyfunctional Gold-Iron Oxide Nanoparticles Loaded with Therapeutic microRNAs for Combined Theranostic Multimodality Imaging and Presensitization of Glioblastoma to Temozolomide. Biomaterials., 2019., 218., 1193422019.
• S. Uday Kumar and P. Gopinath. Fabrication of nanofibrous scaffold grafted with gelatin functionalized polystyrene microspheres for manifesting nano-mechanical cues of stretch stimulated fibroblast ACS Appl. Biomat.., 2019., 2., 12., 5323-5339.
• T. D Illani., R J Bose., S Uday Kumar., S Bachawal., H Wang; A Telichko., C Herickhoff., E Robinson., S Baker., J. G. Vilches., S. A. Felt., S. S. Gambhir., R. Paulmurugan., J. D. Dahl. Ultrasound/microbubble-mediated targeted delivery of anticancer microRNA-loaded nanoparticles to deep tissues in pigs ‎J. Control. Release., 2019 309: 1-10.
• J. C. B. Rajendra., S. Uday Kumar., Z. Yitian., A. Rayhaneh., R. Elise., L. Kenneth., B. Abel., H. Frezghi., S J. Pitteri., S. Robert., J. K. Willmann., T. F. Massoud., S. S. Gambhir., and R. Paulmurugan. Tumor Cell-Derived Extracellular Vesicle-Coated Nanocarriers: An Efficient Theranostic Platform for the Cancer-Specific Delivery of Anti-miR-21 and Imaging Agents. ACS Nano., 12(11):10817-10832.
• Sauraj., S. Uday Kumar., V. kumar., R. Priyadarshi., P. Gopinath., Y. S. Negi. pH responsive prodrug nanoparticles based on xylan-curcumin conjugate for the efficient delivery of curcumin in cancer therapy. Colloids Surf. B 2018.,15; 188:252-259.
• M. C. Ramkumar., K. N. Pandiyaraj., A. Arun Kumar., P. V. A. Padmanabhan., S. Uday Kumar., P. Gopinath., A. Bendavid., P. Cools., N. De Geyter., R. Morent., R.R. Deshmukh Evaluation of mechanism of cold atmospheric pressure plasma assisted polymerization of acrylic acid on low density polyethylene (LDPE) film surfaces: Influence of various gaseous plasma pretreatment. Appl. Surf. Sci. 2018., 439., 991-998.
• S. Uday Kumar., B. Bhushan and P. Gopinath Bioactive carbon dots lights up microtubules and destabilises cell cytoskeletal framework - a robust imaging agent with therapeutic activity. Colloids Surf.., B. 2017., 159.,662-672.
• Sauraj., S. Uday Kumar., P. Gopinath., Y. S. Negi. Synthesis and bio-evaluation of xylan-5-fluorouracil-1-acetic acid conjugates as prodrugs for colon cancer treatment. Carbohydr. Polym. 2017., 157.,1442–1450.
• B. Tirkey., B. Bhushan., S. Uday Kumar and P. Gopinath. Prodrug encapsulated albumin nanoparticles as an alternative approach to manifest anti-proliferative effects of suicide gene therapy. Mater Sci Eng C Mater Biol Appl. 2017., 1(73)., 507-515.
• S. Aiswarya Devi., M. Harshiny., S. Udaykumar., P. Gopinath and M. Matheswaran Strategy of metal iron doping and green-mediated ZnO nanoparticles: dissolubility., antibacterial and cytotoxic traits Toxicol Res., 2017.,6., 854-865.
• M.C. Ramkumar., K.N. Pandiyaraj., A.A. Kumar., P.V.A.Padmanabhan., S. Uday Kumar., P.Gopinath. Atmospheric pressure non-thermal plasma assisted polymerization of poly (ethylene glycol) methacrylate (PEGMA) on low density polyethylene LDPE films for enhancement of the cyto-compatibility Surf Coat Technol., 2017., 329., 25., 55-67.
• K. N. Pandiyaraj., A.A. Kumar., M.C.Ramkumar., S. Uday Kumar., P.Gopinath., PieterCools., N.D. Geyter., R.Morent., M.Bah., S. IsmatShah., R.R.Deshmukh Effect of processing parameters on the deposition of SiOx-like coatings on the surface of polypropylene films using glow discharge plasma assisted polymerization for tissue engineering applications Vacuum., 2017 143., 412-422.
• S. Uday Kumar., B. Bhushan and P. Gopinath. Multifunctional carbon dots as efficient fluorescent nanotags for tracking cells through successive generations J. Mater. Chem. B., 2016., 4., 4862-4871.
• S. Uday Kumar and P. Gopinath. Field-actuated Antineoplastic Potential of Smart and Versatile PEO-bPEI Electrospun Scaffold by Multi-staged Targeted Co-delivery of Magnetite Nanoparticles and Niclosamide-bPEI Complexes. RSC Adv.., 2016., 6., 46186-46201.
• K. N. Pandiyaraj., A. A. Kumar., M.C. Ram Kumar., R.R. Deshmukh., A. Bendavid., P G Su., S. Uday Kumar., P. Gopinath. Effect of cold atmospheric pressure plasma gas composition on the surface and cyto­compatible properties of low-density polyethylene (LDPE) films. Curr. Appl. Phys.., 2016., 16(7)., 784–792.
• S. Uday Kumar and P. Gopinath. Bioactive core-shell nanofiber hybrid scaffold for efficient suicide gene transfection and subsequent time resolved delivery of prodrug for anticancer therapy. ACS Appl. Mater. Interfaces., 2015., 5., 12078-12086.
• S. Uday kumar and Gopinath P. Nanotechnology- A Promising Approach for Suicide Gene Therapy. Austin J Nanomed Nanotechnol.., 2015., 3(1)., 1-3.
• P. Dubey., I. Matai., S Uday Kumar., A. Sachdev., B. Bhushan., and P. Gopinath. Perturbation of cellular mechanistic system by silver nanoparticles toxicity: cytotoxic., genotoxic and epigenetic potential. Adv. Colloid Interface Sci., 2015., 221., 4-21.
• S. Uday Kumar and P. Gopinath. Controlled delivery of bPEI-niclosamide complexes by PEO nanofibers and evaluation of its anti-neoplastic potentials. Colloids Surf. B., 2015., 3., 4843-4852.
• B. Bhushan., P. Dubey., S. Uday Kumar., A. Sachdev., I. Matai and P.Gopinath. Bionanotherapeutics: Niclosamide Encapsulated Albumin Nanoparticles as a Novel Drug Delivery System for Cancer Therapy. RSC Adv., 2015., 5., 12078-12086.
• P. Dubey., B. Bhushan., A. Sachdev., I. Matai., S. Uday Kumar and P. Gopinath. Silver Nanoparticles Incorporated Composite Nanofiber for Potential Wound Dressing Applications. J Appl. Polym. Sci.., 2015., 132., 42473. IF: 2.18
• S. Uday Kumar., I. Matai., P. Dubey., B. Bhushan., A. Sachdev and P. Gopinath. Differentially cross-linkable core-shell nanofibers for tunable delivery of anticancer drugs: Synthesis., characterization and its anticancer efficacy. RSC Adv.., 2014., 4., 38263 - 38272.
• B. Bhushan., S. Uday Kumar., I. Matai., A. Sachdev., P. Dubey and P. Gopinath. Ferritin Nanocages: A novel platform for biomedical applications. J. Biomed. Nanotechnol.., 2014., 10., 2950-2976. IF:
• I. Matai., A. Sachdev., P. Dubey., S. Uday Kumar., B. Bhushan and P.Gopinath., Antibacterial Activity and Mechanism of Ag-ZnO Nanocomposite on S.aureus and GFP-expressing Antibiotic Resistant E.coli. Colloids Surf.., B.., 2014., 115., 359-367.
• S. Uday Kumar., B. Bhushan., P. Dubey., I. Matai., A. Sachdev and P. Gopinath. Emerging Applications of Nanoparticles for Lung Cancer Diagnosis and Therapy. Int. Nano Lett.., 2013., 3., 45.
• A. Sachdev., I. Matai., S. Uday Kumar., B. Bhushan., P. Dubey and P. Gopinath., A novel one-step synthesis of PEG passivated multicolour fluorescent carbon dots for potential biolabeling application. RSC Adv., 2013., 3., 16958-16961.
• G. Bhargavi., I. Matai., A. Sachdev., S. Uday Kumar., P.Gopinath Microwave Assisted Synthesis of Chitosan Nanorods and Assessment of its Antibacterial Activity Against GFP-Expressing Antibiotic Resistant E. coli. J Chitin Chitosan Sci., 2013., 1(3)., 167-172.

Ph.D. Scholars:

• Vinith J: Ultrasound responsive hybrid nanomaterials for liver regeneration

M.S. (Research):

• Sunil V: VOC nanosensor for early pest forecasting

B.Tech Students:

• Bhogavalli Sri Samhitha
• Animesh Ranjan
• Pendurthi Vivek Chetan